Glutamate is the chemical responsible for 90 percent of brain activity. Preliminary data show DXM acts just as quickly.ĭXM and ketamine are part of a drug family called glutamate blockers. Its effects also last long after the drugs leave the body. Where other antidepressants fail, ketamine appears to work-not in weeks, but days, sometimes even hours. One reason the researchers think DXM has potential for treating depression is that it works a little like ketamine, perhaps the most successful street drug thus far repurposed for treating depression. Over the past three years, clinicians at several universities have begun experimenting with hallucination-inducing doses of the drug dextromethorphan (DXM), a common ingredient in several over-the-counter cough medicine brands. And the most recent one to be considered can be found on nearly every drug store shelf: cough syrup. That’s one reason researchers continue to look for surprising alternatives to treat depression. They’re not always all that effective, either: Only a third of people get better on the first antidepressant they take, while less than two-thirds of people get better after trying four different antidepressants. For one thing, they’re slow-taking roughly four to six weeks to kick in.
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